What is the best resource for "safer" MDMA consumption? (Like, which SSRI to take and at what dosage).
Also, isn't mixing SSRIs and MDMA a huge no-no, given the potential for a serotonin storm/serotonin syndrome?
Also, isn't mixing SSRIs and MDMA a huge no-no, given the potential for a serotonin storm/serotonin syndrome?
SSRI:s will give you a strong tolerance against serotonergic drugs and it will take a long time to lower that tolerance, months, maybe a year or two. As far as I know it hasn't been studied scientifically but I've seen people get quite uncomfortable experiences from MDMA and 5-HT2a-psychedelics (LSD, psilocybin, mescaline, those) after being off SSRI medication for several months, that I amateurishly attribute in part to downregulation of serotonin sensitivity.
A more acute risk is MAO inhibitors, which are sometimes prescribed as antidepressives. You're more likely to suffer acute damage or die from a combination of MDMA and an MAOI than with an SSRI, though neither is a good idea.
The Bluelight forums are a decent source of harm reduction advice, https://www.bluelight.org/community/forums/. Be aware that some participants in the discussions have problems with risky or abusive use, or give bad advice. Stickied guides tend to be of high quality, however.