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I haven't tried it but Arq has a good reputation.

I’m using Arq which backs up to a Hetzner storage box. Cheapest €/TB I could find.

Much data, medium risk tolerance: Mega

Small data, or low risk tolerance: Tarsnap

Tarsnap restore times are crazy slow. Avoid.

We replaced with Borg.

I have no experience with them but I have heard good things about rsync.net. They use ZFS.

I use Jottacloud, which is quite similar in many respects.