A 100x100 thumbnail that was reduced from a 1000x1000 image might have pixels which are derived from 100 samples of the original image (e.g. a simple average of a 10x10 pixel block). Or other possibilities.
As an abstraction, a pixel definitely doesn't represent a point sample, let alone an infinitely small one. (There could be some special context in which it does but not as a generality.)