Could also positively affect offspring if spermatogenesis is blocked at the right step, stopping the gamete progenitors from accumulating somatic mutation. The majority of rare genetic diseases arising from de-novo mutations has its origin in the fathers gamete formation (with increasing risk (i.e accumulation of mutations) at older paternal age). Maybe this could block/slow down this process (i.e cell division) and in 20 years all males that still may want to have kids will take a RARα blocker.