An LSD Analogue with Potential for Treating Schizophrenia
ucdavis.edu
ucdavis.edu
JRT promoted neuroplasticity, or growth between cellular connections in the brain, leading to a 46% increase in dendritic spine density and an 18% increase in synapse density in the prefrontal cortex.
JRT did not produce hallucinogenic-like behaviors that are typically seen when mice are dosed with LSD. JRT did not promote gene expression associated with schizophrenia. Such gene expression is typically amplified with LSD use.
JRT produced robust anti-depressant effects, with it being around 100-fold more potent than ketamine, the state-of-the-art fast-acting anti-depressant.
JRT promoted cognitive flexibility, successfully addressing deficits in reversal learning that are associated with schizophrenia.