Yeah I've been running the Arch variant of this on my personal laptop for a while now. Of course no stability guarantees with this for now since you'll be running systemd from source.
Aside from that, I'm using flatpak for firefox and for some reason it takes absolutely forever (like > 15s) to start firefox on my machine, still need to look into why that happens.
Aside from those it's very usable. But of course it's running systemd from source so I'm not going to actually recommend anyone to run this who is not a systemd maintainer until we iron out the kinks.
The slow startup times have usually been an xdg-desktop-portal issue for me in the past, might be worth looking into.