Full article is paywalled, but the point remains. Point is that scale matters, obviously.

Almonds contain trace amounts of amygdalin, you can eat a handful of almonds every day of your life, but if I asked you to eat a kg in one sitting, you're not gonna have a good time.

Plastics have gone from niche to absolutely ubiqutous worldwide in ~100 years. Even if it turns out to be totally and completely harmless to humans and every other animal, wouldn't you want to know that for sure?