In the 1960s a Canadian research expedition collected soil samples from Easter Island which led to the discovery of rapamycin (aka sirolimus).
https://en.wikipedia.org/wiki/Sirolimus
https://pmc.ncbi.nlm.nih.gov/articles/PMC9634974/
(Full disclosure - spent my PhD working with macrolides including this one. It's an amazing origin story for a compound...)