I always liked this idea; but wouldn't you run into issues with file permissions? And if not, wouldn't that mean that the program in question would have access to all your files anyhow, removing the benefit of isolation?
I use scripts to automate everything - including allowing wine to use Xwayland (because until I start the application I want, its userid is not allowed to show content on my display)
If you want to try using wine with different user ids, try to start with a directory in /tmp like /tmp/wine which is group writable, with your windows app and your user belonging to the same group.