The next step is to isolate the Windows applications: you could use different WINEPREFIX, but I think the better way is to do it like android: one "user" per application.
It's not just to prevent applications to read other applications files, but also to firewall each application individually
For example, if you don't want the application you've mapped to user id 1001 to have any networking, use iptables with '-m owner --uid-owner 1001 -j DROP'
I moved from Windows to Linux a few years ago, I have a few Windows apps I still love a lot (mostly Word and Excel) and thanks to wine I will always be able to use them.
They are also extremely fast: cold starting Word (or Excel) on my laptop takes less than a second, and use far less RAM
Personally, I'd rather purchase a few shrink wrapped old versions of Office from ebay than bother with LibreOffice, Abiword or the online version of Office.
EDIT: I can't find the old recording I made showing how fast it was, but here's what it looks like on my hypland desktop: you can see in btop it doesn't take much resources
https://www.reddit.com/r/unixporn/comments/11w3zzj/hyprland_...