Actually, even a glance at my GPS while driving wil occasionally cause a twinge.
So it's more up to the individual in question, then the driver (considering a normal, average car ride, not anything in the extremes).
I've always worn glasses but my vision has gotten progressively worse as I've aged - it's not bad, even now, I can legally drive without glasses - but it's enough to be noticeable.
I also was much less prone to motion sickness when I was younger - I would happily read full novels while riding along as a grade schooler.
Turned out that I had similar issues, just not noticeable. It had to do with my eyes not being able to properly maintain a focus at a specific distance over time, and their ability to track properly. I've always been a slow reader - this is at least partly why. I was told that it's also responsible for the fact that I get car sick within seconds of reading in the car, and that it goes away with therapy. Unfortunately, I never did go through with the therapy.
As it happens, the same types of driving that are more fuel efficient cause less motion sickness. Still, driving anywhere with stop lights and other traffic probably necessitates enough stopping and starting that even maximally efficient driving software would cause motion sickness in many people.