Old-school computer security breaks things down into the CIA categories:
Confidentiality is for things you want secret. Integrity is for things you want to not be altered. Accessibility is for things you want to be able to reach.
Honestly, very little of data requires confidentiality. Yet that's what encryption is usually used for. I would, by an order of magnitude, rather have a hacker gain access to my family photos than have them deleted beyond my ability to recover.
I hate whole-disk encryption. In nearly everything in my life, the threat of losing access to my data is vastly worse than someone else accessing it.
I run a business. A good deal of what is on my laptop I would put in the confidentiality category. I guess apps and settings would come under integrity.
Keep an unencrypted backup in a secure location, not on a device you are bound to lose in a coffee shop or airport.