I'm doing it right now as I'm applying to and interviewing with startups and more established companies in SF/SV. Even though my domain seems to be in really high demand right now (data science/network analysis) I'm trying to be gracious, quick, and communicative with potential employers because I want to indicate that I'm that kind of person in a team environment in addition to my technical assets. It seems to be working pretty well so far, especially with smaller shops that are moving quickly. In the words of one founder I spoke with today, "we have a hiring timeframe of yesterday" and I think it is important to show them you are rarin' to go.
As a side note - if you are applying to startups, write your cover letters while sitting in SF/SV coffee shops that are known startup hotbeds. If you strike up friendly conversations with random folks wearing the right t-shirts you'll often get recommendations to apply to places you've never heard of, perhaps with a friendly "in" if you can impress them by being a personable, well-balanced individual.
As a shameless plug, hit me up if you are looking for a data geek or someone who honestly loses sleep over graph algorithms.