The only metric I can think of that was impacted was currency value on the day of the vote, but that dump was driven by predictions of economic problems that never happened so arguably those traders just took a bath due to believing the wrong people. It is anyway not necessarily bad for a country like the UK to have a lower valued currency; economists had for years been arguing it was overvalued and would be better if the currency was cheaper, so this is a bit of a wash.
All the comments being made here about people voting against their own interests start by assuming that voter's interests are exclusively trade-related, and that constitutional issues don't matter to people at all. This is clearly wrong but a required assumption for the whole against-their-own-interests claim to work. And then it goes on to conflate predictions with reality, by assuming that because the NGO-academic class predicted economic doom it must have actually happened when it didn't.
Both of these are fatal flaws to the argument.
The only way I can see to argue there was negative impact is via very indirect paths, e.g. the voters wanted less immigration and Johnson set the thresholds in the new immigration system so low that immigration increased. But that's more accurately blamed on the Conservatives and the general ideological hangover of EU membership on the party itself, not leaving. Voters can at least do something about it now, and the rise of Reform (Britain's new top-polling party) is evidence of that effect in action.