To the brain, Esperanto and Klingon appear the same as English or Mandarin
news.mit.edu
news.mit.edu
Conlangs also tend to be based, consciously or subconsciously, on existing natural languages. As I understand, Esperanto is largely Romance language vocabulary with Slavic language grammar.
Lagniappe: https://www.youtube.com/watch?v=gv0QIbGc8i8
> To further refine the features of language that activate the brain’s language network, Fedorenko’s lab is now planning to study how the brain responds to a conlang called Lojban, which was created by the Logical Language Group in the 1990s and was designed to prevent ambiguity of meanings and promote more efficient communication.