They are very different as far as I know:
The second step, Orient, does not include making hypotheses. It's about forming a picture or concept in your mind of the situation in which you have to act.
There is nothing in OODA about hypothesizing or testing; you are quickly forming a final conclusion and acting - it's almost the opposite of science, in that regard. It was created for fighter pilots; a failed hypothesis would often result in death and be your last thought.
Science and aerial combat are very different: Science has time to be methodical and it experiments to uncover an absolute truth; in aerial combat you must make final, 'good enough' decisions as quickly as possible, because taking time results in failure.