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Their microdosing experimentation was questionable. Not methodically, it was quite thorough, but iirc they used unknown strength street blotters and derived all further experimentation from that.

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As I always point out, all of the anecdotes claiming microdosing works are usually using street blotters as well, including the research papers which draw on crowdsourcing to circumvent the obvious problems with using schedule I psychedelics; and the research papers which do use better-validated dosages... don't usually turn up anything more than I did. Plus, it's 2025. If LSD microdosing really worked, after all this interest over the past 15+ years, why is there still so little good evidence?

I can't tell you why, but the fact that LSD is a schedule 1 drug with a strong stigma and that it's a drug that can't be patented will severely hamper any study efforts.

Some current theories re: microdosing efficacy that I've seen are that people who report benefits from microdosing (beyond placebo) are inadvertently self medicating ADHD symptoms, which seems plausible, given LSDs stimulant effect and 5HT2A affinity.

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