Lots of critical things for the US is made exclusively in Europe.
Lots of medicin that people rely on daily would be unavailable if EU/US trade broke down completely.
About half of the US companies over a certain size run on ERP software from an European vendor. And it is not trivial at all to change that, even if they wanted to.
A real untangling of the US and European economies seem both impractical and really inefficient.
I've worked with airgapped Windows XP machines still in operation running scientific instruments.
If you deleted Microsoft and Apple from world it world it would be a Y2K event but the world wouldn't end, it would just be a lot of work.
Sibling in thread says there's already an US alternative, anyway.