Here is a tip that I just recently learned that has improved my browsing experience with uBlock Origin. In the settings menu under "Filter Lists" there sections under the heading of "Cookie notices" and "Annoyances" that are not enabled by default. Blocking cookie popups has been wonderful, and I can only imagine what kind of annoyances are now being blocked for me.
I don't trust random sites on the internet to follow the law anyway, so nuking your cookies and localstorage when you close the browser or navigate away is what you should be doing if you're concerned about this sort of thing. Obviously sites I need to stay logged into get on the allowlist.
luckily some kind soul her pointed me to the cookie autodelete extension. Which does just this. I am able to add the three sites I want to keep persistence as exceptions and just let everything else burn after a day. The fun part is how it trips the firefox "looks like you have not used firefox in a while" dialog every single time. I don't fix it because that is how I know it is working
TLDR: Blocking cookie popup = not allowing cookies.