This is study is European, but still shows the issue:
https://www.euda.europa.eu/news/2024/4/latest-wastewater-dat...
At the nanogram level? Forget it. There's all kinds of crap in everything we eat, drink, and breathe. Dose makes the poison - there's a big difference between a detectable level of something and a clinically significant amount. You'd be better off improving the ventilation in your house than worrying about whether your lettuce has 1PPT of cocaine metabolite in it.
Note that all of the above is about the party drugs. I have no idea about what the deal is with the psychiatric meds and hormones. If anyone has knowledge of whether chronic exposure to extremely small quantities of them and their métabolites has clinical significance I'd be interested to know more. I sort of doubt it, but I'd be happy to be proven wrong