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Guess: headache from low frame rate?

Indeed.

I legitimately thought it was some DOS compatibility layer or something. Like, you’d have to run Doom that way because of the low framerate natively.

With every interesting word in the dictionary having been used to name products by now, the confusion is understandable.

edit: although ibuprofen is a brand name.

Ibuprofen is the generic name for the drug. There are branded variants like Nurofen if you want to spend more money for no real reason.