Research grants are ripe fruit to university administrations. But the new guidelines limit the cut a sponsoring institution can take out of a federal grant to 15%.
For instance Texas medical schools/institutions would previously take as much as half the money in a US grant from the researcher and use it for whatever they wish. I believe Trump's measures are intended to cut back on such situations.
I'm fairly certain the institutions will find a way around Trump's measures, given time. It's a cat-and-mouse game.