When you use an active placebo like atropine, something that makes you feel "different" like SSRIs do, it is even worse.

https://pubmed.ncbi.nlm.nih.gov/7037102/

https://sci-hub.se/https://www.thelancet.com/journals/lanpsy...

>Many years ago, adequately blinded trials of tricyclic antidepressants were done, in which the placebo contained atropine, which causes dryness in the mouth like the active drugs do. These trials reported very small, clinically insignificant effects of tricyclic antidepressants compared with placebo (standardised mean difference 0·17, 95% CI 0·00–0·34).