A simple policy could easily end those supply chains and large distributors. Just legalize it. Coke, meth, heroin. Legalize it, only allow it to be sold retail (no more street drugs), only allow licensed manufacturers to produce it, only allow them some very modest (capped at 2% over cost, maybe) profits. You get to choose where it's sold (out of liquor stores, most likely, instead of crack houses). You get to starve the cartels to death (they're cut out completely). No cops dying in shootouts, no dealers dying in shootouts, no bystanders dying in shootouts. And if you want tweekers to stop stealing copper wiring for scrap, just get rid of piss tests too... if drugs are so awful that people who give suck dick for it, then they're also so awful that people will get a minimum wage job scrubbing toilets for them. It's just that they can't because of piss tests.
Instead, we'll get another 100 years of half-assed decriminalization, where it's still illegal to sell, dealers are still motivated to kill cops, deadbeats, and rivals, where 100,000 people die because it's laced with fentanyl and even decriminalized illegal street drugs can't be regulated. I eagerly await all the downvotes this opinion will get.