Firefox of course. It has the most add-ons, most compatibility/support with other sites, services, software. And it has fewer bugs than newer browsers. If you just want a general purpose browser, Firefox is it. Chrome is always an option too, and they certainly have some useful extra features, but they'll also remove support for things if it conflicts with Daddy Alphabet.
Librewolf or Ungoogled Chromium with uBlock.
Ungoogled Chromium removes those pesky manifestv3 changes as well? The ones which make uBlock basically non-functional.
I don't think so, but in practice when running uBlock on Chrome I still don't see ads. It's less efficient under the surface but the user experience hasn't changed significantly.