Substance in broccoli, celery inhibits graying of black hair
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> https://www.mdpi.com/2076-3921/13/12/1549
The human equivalent dose of luteolin would be about 3g/day, which is a lot -- but this makes it more interesting, for although luteolin has been available as a nutritional supplement for decades, I don't think that people have normally taken it at that sort of dose. Or anywhere near that sort of dose.
Luteolin is a weak yellow dye, but there are presumably ways to formulate it for topical use so that it's colorless. In general, it's usually pretty easy to get chemicals into follicles. (As opposed to through the skin, e.g. with a nicotine patch, which is possible but more difficult.) If this stuff works, it'll be a staple of haircare and anti-aging products for decades.
It's not in that particular study, but more potent analogs appear to exist. They lack luteolin's easy off-the-shelf availability, though, and presumably the mechanism of action is the same at any rate.
You’re over thinking it.
I tried Luteolin at clinically insignificant doses both as a nutritional supplement and in this really expensive hair care product and not only did it regrow my receding hair line, colour my hair unnaturally black, and marry someone half my age, if you buy one month supply right now at this exorbitant priced we’ll throw in a set of stake knives.
IT REALLY WORKS!
S-adenosylmethionine is presumably involved in its metabolism and excretion. This doesn't imply that you'd want to take SAMe with your luteolin dose.
https://www.frontiersin.org/journals/molecular-neuroscience/...
"The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation"
Stem cells, but still ...
What's more: "Luteolin exhibits limited blood-brain barrier permeability (−0.907) and CNS permeability (−2.251), indicating poor penetration into the brain."
> https://www.sciencedirect.com/science/article/pii/S222541102...
So if 15µm concentrations are unattainable in plasma, the brain would be exposed to much less still.
In animal experiments, as noted in your link, luteolin appears beneficial. There could be a dose-response-curve thing, where reasonable (physiological) amounts are neuroprotective, whereas exposing cells to very high concentrations directly is damaging.
Radicchio looks to have the highest content of Luteolin.
And it was applied topically by rubbing the substance on their fur.
> Oral administration of luteolin provided similar results.
So taking it as a pill might be good enough.
I read, somewhere, that Cleopatra had lead combs.
Never really paid much attention, other than being annoyed by the ads.
Until 2018 the formulation used in the United States contained lead(II) acetate. Because lead acetate was banned in cosmetics in Canada and the European Union, the formulations sold there did not contain it.
That's an awful lot.
Green peppers are rich in luteolin, but you'd need to eat roughly 2500 peppers per day. It's rather more efficient to (a) take a synthetic supplement, or, even better, (b) deliver the stuff directly into follicles.
Seems so, although I can see taste being a barrier for many.
I'm 35 and really rather grey.
Also, if they plan on developing a treatment that stops hair going grey, what's the ultimate benefit against just using hair dye?
Permanent hair color generally contains PPD to penetrate the hair cuticle so the dye can actually bind to the hair. That stuff is notorious for causing wicked allergic reactions and sensitizing users over time.