Two main things I noticed:
1. Office distractions were MUCH harder for me to deal with than home distractions. Distractions at home are generally things I self impose and can control with will power (i.e., not playing with the cat, not turning on the TV, not getting a snack, etc.)... but in the office there was stuff going on all around me and no way to shut it out.
2. The guy sitting next to me was sick -- when I got back to my home office two weeks later, so was I. (Granted, travel could have been a factor here -- I live in the US and their offices are a 20 hour plane ride away in Australia.)
Oh, I hear the bug went around the entire office after I left, too.