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Comment by quchen | Hacker News Reader

It is however not unheard of, or even uncommon. With moderate tolerance, binging a couple of hours will reach the 1g threshold quite quickly.

Ketamine tolerance upon continued use can reach some really wild levels. I’ve worked with people who reported that a 1g single dose nasally won’t get them properly high.

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Wow, I googled and the dose for horses is about 2 to 5 mg/kg

It’s the same dose (per body mass!) for humans, and ketamine is heavily used in human medicine for similar reasons. The main difference is that for horses it’s mostly used as an anesthetic, while for humans it’s also used at lower doses as an analgesic (pain reliever).

Yeah but I mean, 1g is a 200kg human dose in the best case. That's a lot

When I severely dislocated my shoulder the hospital sedated me with ketamine and propofal. They'd already given me the max dosage of morphine and fentanyl to get me to be able to barely sit up for an X-ray.

So I'd say it's used in humans for anesthetic too.

And guys, I'd the doc says after your first dislocation you should have the surgery to prevent it from happening again, you should listen to them so you don't spend a night in excruciating pain three months later.

For what it's worth, when I came too I felt like I was black out drunk, not a good experience for a previous alcoholic

It should be noted that in this example we are comparing insufflation vs injection, which has a very different bioavailability and effect on the body.

I think for therapy with humans it is also given as a nasal spray.

Oh definitely, I thought about writing about it but omitted it, I should have added it earlier

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