A plug for Django + gevent in this context! You have the Python type system, and while it's inferior to TypeScript's in many ways, it's far more ubiquitous than Ruby's Sorbet. For streaming and any kind of IO-bound parallelism, gevent's monkey-patches cause every blocking operation to become a event-loop yield... so you can stream many concurrent responses at a time, with a simple generator. CPU-bound parallelism doesn't have a great story here, but that's less relevant for web applications - and if you're simultaneously iterating on ML models and a web backend, they'd likely run on separate machines anyways, and you can write both in Python without context-switching as a developer.