No issues with NextDNS (I've deployed it for people who don't have the chops to wrangle a Pi-hole), but this reads very, very much like an ad.
That aside, I've had pretty much the same issues with NextDNS that I've had with Pi-hole -- issues that have nothing to do with the infrastructure per se. (The classic example is of an app that doesn't work because domain `X` is being blocked, thus kicking up the usual 15 - 30 minute-long log search and DNS cache-clearing to find and whitelist the domain.)