I wouldn't run the whole script blindly. You will have to do more than one linear pass through the script to find and invert settings you later discover you don't like.

I recommend one close readthrough, uncommenting or commenting things you do or don't like, and then a full run. I do recommend running the script after a careful edit. It will save you time.

I have to recommend against a lot of the items of this script. Having carefully read through it, I can say that more than half of these are not reasonable changes for hacker defaults. My tweaks are more sysctl oriented vs these, although a few can be useful, but ymmv depending on how you are accustomed to working or if you want some of the new benefits, which I find quite useful, in X.8.

There's plenty I wouldn't want. God forbid this alone:

# Trackpad: map bottom right corner to right-click