With DOSBox-X, and probably some other DOS emulators as well, you can set up any SVGA BIOS graphics modes you want to (up to at least 32-bit color with 16-bit integers for screen width and height), so a DOS application using just the standard BIOS functions can run in fullscreen on a modern monitor.

A bit trickier if you want to run on real hardware, especially since BIOS support is basically gone now. Not sure how old hardware you have to go back to to even boot up FreeDOS. I ran it on some late 00's hardware and everything runs insanely fast. I did not remember computers could be that responsive and not annoying to use.