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You can remap the prefix key...

I think the point of their comment is that if you're constantly connecting to different remote servers, you're not going to want to have to change the config on each server remotely. It's the same argument for understanding base vi as well and honestly does come in handy, but it's very discipline specific, most people don't have to worry about this use case.

In that case you’d probably want to change your local config away from the default.

But this is all very silly, I mean, of course there are workflows that aren’t assisted by terminal multiplexers. I’ve heard rumors of jobs out there that don’t even use computers. Adding one more job to the pile that doesn’t need the tool doesn’t say anything about the cases where it does come in handy.

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