It was a quadruple loss - losing the company I wanted to continue, losing my mother (who had provided emotional support), my father (who had previously been full of good advice), and then realizing that the support system that remained was not available.
Obviously this is different from losing a partner and father-of-a-child to cancer, but emotionally I recognize my own state ca. 2.5 years ago in this article - complete with the realization that the person I was before all of this is not around any more.
For quite a number of people the early 40s have some pretty brutal transitions in store.
That said, the nadir of the grief and loss is also in the rear-view mirror, and a few years later things are definitely looking up. We may not be the person we used to be, but there is such a thing as wisdom, and I think I have a much more nuanced and empathetic world view today, and a deeper appreciation of the value of lifetime.