If it helps, here’s info from Dr. Derek Lowe, a 30+ year pharma chemist and author of In The Pipeline. For further research on the topic, he has many other posts on the topic, some of which are linked in the links below.

https://www.science.org/content/blog-post/aduhelm-again

https://www.science.org/content/blog-post/goodbye-aduhelm

https://www.science.org/content/blog-post/alzheimer-s-and-in...