I was forced to use my computer mouseless for a couple of months recently (due to problems with the USB ports). It wasn’t a huge issue since I had things set up mouselessly to start with: with the combination of Sway, Vimium, Emacs, zathura [0] and warpd [1] it was quite tolerable. That said, I’m happy to have my mouse back now — there’s just too many applications which assume that you have one.