No it couldn’t, operating a drone isn’t „driving a vehicle“ as required for vehicular manslaughter in California. And vehicular manslaughter isn’t murder either.
Now I will grant you, a good defense lawyer would try to claim that killing someone with a remotely operated drone does not constitute "the operation of a motor vehicle, aircraft, or water vehicle that results in injury or death" but if you squint, it just might if they could prove intoxication.
I looked here:
http://leginfo.ca.gov/pub/07-08/bill/asm/ab_0651-0700/ab_678...
And the only single mention of „murder“ is for placing highway signs.