We don't have the capacity to do that internally, but we were thinking about having a "Community Guides" section of our docs where people could contribute guides to setting up Mathesar on different infrastructure. Let me know if that's something you'd be interested in contributing to!

I think the better way to achieve that would be just using the Docker container.

There should be any notable performance decline, since the Python backend is just an API proxy towards PostgresSQL database servers.