Different lineages, for sure. Clojure really stands on its own in the lisp world and some die-hard lispers claim that it's not a lisp at all. However, for Clojure devs, I think we generally aren't interested in using the other lisps in practice, for building practical software. We just appreciate them for their lispiness. So the main difference will be that LispE is more like CL than like Clojure.
Aside from that, LispE is interpreted, whereas jank is JIT compiled with full AOT compilation support, using LLVM. By using Clang/LLVM, jank also has full access to C++ interop, whereas most interpreted lisps are sandboxes on their own.
I'm not familiar with this side of traditional lisps very much. Someone may be able to jump in to embellish or correct.