I e experienced a few “gotchas” using uv (or uvx) as a command runner, but when it works (which is most of the time) it’s a big time saver. As a Python dev and curious person my homedir is littered with shallow clones and one-off directories for testing some package or another, and not having to manage this overhead is really useful.

OP, you have a great idea and I’m stealing it. Do you use some non-.py suffix, or is seeing the exec bit at on a .py file enough of a signal for you to know that you can just run the file as a script (and it won’t use the system Python)?