Of course not, but there's a difference between disagreeing with which is the best recipe for a cheesecake, the best castle in France, or whether or not it's acceptable to invade your neighbouring countries, if the government should be following the law/constitution, or basic biology, etc.
Some opinions one disagrees with are very worth to be up in arms. I'd even say that people have a civic duty of being up in arms against certain egregious topics. Say if a politician says that they want to allow for 9 year olds to be married to adults; or a rich guy backing multiple politicians all over the world Sieg Heils on national television; or a politician that just got elected is asking for money for favours from companies; or there's talk of "other"ing significant swathes of the population.