"Manganese is essential for various cell functions, but chronic exposure causes a neurodegenerative condition with symptoms resembling Parkinson’s disease. Lai et al. developed an adult fly model of manganese-induced parkinsonism and found that altered metabolism of biotin (also known as vitamin B7) mediated the metal’s neurotoxicity. Manganese exposure reduced the amount of “free” or bioavailable biotin, which resulted in neuronal loss and mitochondrial and lysosomal dysfunction in the brain and impaired motor function. Supplementing the flies’ diet with biotin alongside manganese exposure prevented these effects. The cellular effects were reproduced in cultured human dopaminergic neurons. The findings suggest that supplementary biotin may be a preventive intervention for at-risk individuals."
I have an idea of why Biotin lowers Manganese if anyone is interested!
Hint: https://www.uniprot.org/uniprotkb/P11498/entry