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But is there really a fundamental difference between an ISP and a big internet portal with respect to the value of neutrality?Everyone is responding that legally, yes, there is.
But you're asking about whether there's a logical difference.
Yes, there still is. Your ISP is the only data pipe into your house; if they don't let certain data in, you literally have no other way to get it. (Other than by using a hotspot on your phone, but that data is also provided by an ISP.
Whereas Reddit is just an aggregator. They collect links. You can get those links from elsewhere - other aggregators, or by directly going to the website, etc.
Saying that Reddit & subreddit mods shouldn't be allowed to block links to twitter is like saying that since the USPS can't refuse to deliver your mail, then the Washington Post should be required to print copies of the New York Times in the middle of their printed edition.