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Comment by malfist | Hacker News Reader

Nonsetrile compounding, like you'd do from the peptide sites is only safe for immediate use, and semaglutide is not that way. You mix up a vial and use it for a month or so.

Can you do it? Sure. Are you going to get an infection from it? Probably not. Is it riskier than having a compounding pharmacy doing it the right way? Absolutely, and in a meaningful amount of risk. The type of infections you get from contaminated injections are not something you want to deal with

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It comes as lyophilized powder. You reconstitute the drug yourself and follow WHO sterility guidelines (reconstitute with bacteriostatic water, alcohol wipe ampoule top before accessing, keep it in the fridge, and throw it out if you havent finished it within 30 days). I know a dozen people doing this for the last year and none of them have had any sign of even superficial infection.

I think the way it works when you get bacteria into your blood is either you have no noticeable symptoms, or you get a high fever and almost die from sepsis.

People with minimal training drew up billions of doses of covid vaccines from multi-use vials and administered them intramuscularly (deeper and therefore potentially more risky than subcutaneous ozempic/mounjaro) and I never heard of anyone getting an infection from this

Importantly, they weren't the ones mixing the vials. That's the missing piece here. The vials were already sterile.

Those are wise safety procedures, not that's not sterile compounding. EVERYTHING needs to be sterile. The needles used for mixing, the air in the room, the hood you're mixing it in, everything. The room or hood has to be in positive pressure, and the ampule needs to be at a partial vacuum.

What you're describing is a adequate for immediate use. Not use and storage.

Wiping the bottle before use is just standard practice to prevent contamination after compounding.

Everything I said is equivalent to the WHO vaccination programme reconstitution and administration procedures. Vaccine clinics use multidose ampoules for up to a month. These aren’t sterile compounding pharmacies.

Haven't done it myself but there is a robust DIY community for GLP-1 drugs. No idea if anyone's gotten hurt yet or if it's been pretty okay so far.

Oh sure, there absolutely is. Not only for glp-1s but for all kinds of peptides, especially SARMs.

Doesn't mean it's safe. Lots of people trade off a small risk of harm for immediate benefits. Hell, look at alcohol.

I found a pack of 10 5mg bottles in a Discord group for $90 For me that would be a year's worth. Comes with 3rd party testing. Haven't pulled the trigger on that deal yet but I do have some I got for $50 for a 5mg bottle and that's still a hell of a deal. So far so good.

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