Well, depends on your layout. That might be the case on a US keyboard but for many others (for example German, Spanish, the Nordic countries' layout and many other European and non-European layouts) it would be preferred over for example "//". For "//" you need to use a modifier (just as with '#') but you need to stretch more (or use both hands) and as well tap it two times. That's one of the reasons why I prefer to code using an English layout in my IDE/editor :)

"Inconvenient" because typing a # requires a modifier key on most keyboard?