> The appeal is to have a diet more in line with our evolutionary past.
Okay, where in the evolutionary past did we eat Doritos colored with annatto?
> A) derive it from something humans have been eating for hundreds of thousands of years and that a couple studies have confirmed is probably safe...
A lot of things we have historically eaten are carcinogenic. Natural flavoring for root beer is flavored with sarsaparilla root. Fun fact, it contains safrole, a known carcinogen.
Carrots, bananas, parsley, black pepper, clove, anise contain alkenylbenzene compounds which cause cancer in rodents.
We've historically eaten coumarin-containing plants (tonka beans, cassia) -- carcinogenic.
Furoanocoumarins in parsnips, celery root, grapefruit, etc, can cause skin burns and prevent many drugs from working (or make them work too fast).
Cassava, sorghum, stone fruits, bamboo shoots and almonds contain cyanogenic glycosides which turn into cyanide when eaten.
Undercooked beans contain lectins, and 4-5 kidney beans are enough to cause somachache, vomiting and diarrhea.
Nightshades (tomatoes, potatoes, eggplants) contain solanine which is toxic.
Various fruits like pineapples have raphides which are sharp spikes made of oxalic acid. If you eat particularly aggressive ones they can even cause bleeding.
The pawpaw fruit that has been eaten for generations contains annonacin, a neurotoxin.
People have been eating (prepared) mushrooms like gyromitra that have gyromitrin (metabolized to monomethylhydrazine, rocket fuel, a neurotoxin) for generations too. It can actually cause ALS over time.
Castor beans contain ricin.
The difference is apparently God doesn't have to publish this information on an ingredients list.
> B) derive it from petroleum (as current US yellow food dye is) that a couple studies say is probably safe.
"A couple studies" is wildly disingenuous. A quick search will tell you as much.