I seriously don't see any disadvantage in picking Firefox over Chrome. I still have Chrome around if any website requires it specifically, but I haven't launched it in ages.
There were a few Chrome extensions that weren't there on Firefox [1] [2] but I fixed that _easily_ by getting the crx file, unpacking it, then adding the https://github.com/mozilla/webextension-polyfill to the extension to make it cross-browser.
It's easy enough to make an extension work on both Firefox and Chrome, I've done it myself with SideHN (https://github.com/alin23/sidehn), but I guess Firefox is not really in the mind of Chrome extension devs.
[1] https://chromewebstore.google.com/detail/anchor-headings/lgg...
[2] https://chromewebstore.google.com/detail/xpath-helper/hgimno...