I'd recommend listening to the first hour of the podcast this is taken from just as he was more candid than I thought he would be.

Zuckerberg at points brings up how the EU as is very defensive and has taken social media companies to court for the sum of 30 billion (never mentioning why). He laments how the US government need to be more protective of US tech companies overseas specifically naming the EU. When talking about Dana he says how he will explicitly help with them work with difficult foreign governments (be that through how he did it with the UFC or his relationship with the new administration).

It sounded quite like they're preparing to more confrontational with the EU and he at one point mentions how he thinks the new admin is going to protect them more with foreign countries.