It feels unstoppable, which is why the best I can do is try to mitigate its impact. Some mitigations that come to mind:
The development environment where I'm downloading random libraries is on a completely separate physical machine than my primary computer. I generally spin up a short-lived container for each new coding project, that gets deleted after the resulting code I produce is uploaded somewhere. This is completely separate from the work-supplied machine where I hack on my employer's code.
On my primary computer, my web browser runs in an ephemeral container that resets itself each time I shut it down. My password manager runs in a different, isolated, container. Zoom runs in a different, also isolated, container. And so on.
Wherever possible, I avoid letting my computer automatically sync with cloud services or my phone. If one is compromised, this avoids spreading the contagion. It also limits the amount of data that can be exfiltrated from any single device. Almost all of the persistent data I care about is in Git (I use git-annex for file sync), so there's an audit trail of changes.
My SSH and GPG keys are stored on a hardware key so they can't be easily copied. I set my Yubikey to require a touch each time I authenticate, so my ssh-agent isn't forwarding authentication without a physical action on my part. I cover my webcam when not in use and use an external microphone that requires turning on a preamp.
I try to host my own services using open source tools, rather than trust random SaaS vendors. Each internet-facing service runs in a dedicated container, isolated from the others. IoT devices each get their own VLAN. Most containers and VLANs have firewall rules that only allow outbound connections to whitelisted hosts. Where that's not possible due to the nature of the service (such as with email), I have alerting rules that notify me when they connect somewhere new. That's a "page" level notification if the new connection geolocates to China or Russia.
I take an old laptop with me when traveling, that gets wiped after the trip if I had to cross a border or leave it in a hotel safe.
I have good, frequent backups, on multiple media in multiple offline locations, that are tested regularly, so it's not the end of the world if I have to re-install a compromised device.