There is no such thing as polluting substances, only an accumulation of those. The problem lies in the fact that our technological process graph has too many sinks leading to an accumulation of 'dead-end' by-products. There is almost never such occurrences in nature, and when it does (great oxygenation event), the system manages to circle it back into the process graph.
Contrast this with current ecological recommendations: they boil down to reducing the production rate of such substances, which can only asymptotically delay the looming apocalypse.